Process for removing toxins from protein solutions

Details Process for removing toxins from protein solutions Process for removing toxins from protein solutions

1991-04-09

1992-08-04

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530380, 530394, 530395, 530412, C07K 322, C07K 328

Patent

active

051360268

ABSTRACT:
A process for removing toxins from solutions of proteins, in which an aqueous solution of a protein which contains a buffer substance, a chelating agent and a detergent is subjected to an ion exchange chromatography, is described.

REFERENCES:
patent: 4372888 (1983-02-01), Hjelmeland
patent: 4990597 (1991-02-01), Lobermann
Randall-Hazelbauer et al., J. Bacteriology, vol. 116(3) pp. 1436-1446 (1973).
Biochem. 8(10):4063-67 (Oct. 1969), McIntire et al., "Studies on a Lipopolysaccharide from Escherichia coli. Heterogeneity and Mechanism of Reversible Inactivation by Sodium Deoxycholate".
Biochem. 18(20):4425-30 (1979), Schwindler et al., "Interaction of Divalent Cations and Polymyxin B with Lipopolysaccharide".

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