Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...
Reexamination Certificate
2006-07-19
2008-12-16
Fortuna, Ana M (Department: 1797)
Liquid purification or separation
Processes
Liquid/liquid solvent or colloidal extraction or diffusing...
C210S650000, C210S651000, C210S661000, C210S198100, C435S239000, C435S415000, C435S412000, C530S390100
Reexamination Certificate
active
07465397
ABSTRACT:
A process is provided for selectively removing protein aggregates from a protein solution in a normal flow (NFF) filtration process. Preferably, it relates to a process for selectively removing protein aggregates from a protein solution in a normal flow (NFF) filtration process and virus particles from a protein solution in a two-step filtration process. In a first step, a protein solution is filtered through one or more layers of adsorptive depth filters, charged or surface modified microporous membranes or a small bed of chromatography media in a normal flow filtration mode of operation, to produce a protein aggregate free stream. The aggregate free protein stream can then be filtered through one or more ultrafiltration membranes to retain virus particles at a retention level of at least 3 LRV and to allow passage therethrough of an aggregate free and virus free protein solution.
REFERENCES:
patent: 4618533 (1986-10-01), Steuck
patent: 5085784 (1992-02-01), Ostreicher
patent: 5464818 (1995-11-01), Yamaguchi et al.
patent: 5466377 (1995-11-01), Grandics et al.
patent: 5547576 (1996-08-01), Onishi et al.
patent: 5629084 (1997-05-01), Moya
patent: 5958244 (1999-09-01), Hartmann
patent: 6117423 (2000-09-01), Berg
patent: 6193891 (2001-02-01), Kent et al.
patent: 6281336 (2001-08-01), Laursen et al.
patent: 6365395 (2002-04-01), Antoniou
patent: 6387877 (2002-05-01), More et al.
patent: 6498240 (2002-12-01), Leonard et al.
patent: 6630195 (2003-10-01), Muralidhara et al.
patent: 6806355 (2004-10-01), Joergensen et al.
patent: 7108791 (2006-09-01), Tkacik et al.
patent: 7118675 (2006-10-01), Siwak et al.
patent: 10114537 (2002-10-01), None
patent: 1203774 (2002-05-01), None
patent: WO 97/32893 (1997-09-01), None
patent: WO 97/45140 (1997-12-01), None
patent: WO 99/19343 (1999-04-01), None
patent: WO 03/066669 (2003-08-01), None
Honig et al, Impact of Design and Selection of Prefilters s on Operating Cost, Filtration and Separation, Gbelsevier Advanced Technology, Oxgord, vol. 34, 1997, pp. 73-78.
An Hong
Comier Jason R.
Kinzlmaier Dana
Siwak Martin
Fortuna Ana M
Millipore Corporation
LandOfFree
Process for removing protein aggregates and virus from a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for removing protein aggregates and virus from a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for removing protein aggregates and virus from a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4030979