Process for removing bile salts from a patient and compositions

Details Process for removing bile salts from a patient and compositions Process for removing bile salts from a patient and compositions

1994-06-10

1997-04-29

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Miscellaneous

210660, 210661, 210903, B01D 1500, B01J 3900

Patent

active

056249632

ABSTRACT:
A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly crosslinked polymers characterized by a repeat unit having the formula ##STR1## or copolymer thereof, where n is an integer; R.sup.1 is H or a C.sub.1 -C.sub.8 alkyl group; M is ##STR2## or --Z--R.sup.2 ; Z is O, NR.sup.3, S, or (CH.sub.2).sub.m ; m=0-10; R.sup.3 is H or a C.sub.1 -C.sub.8 alkyl group; and R.sup.2 is ##STR3## where p=0-10, and each R.sup.4, R.sup.5, and R.sup.6, independently, is H, a C.sub.1 -C.sub.8 alkyl group, or an aryl group, the polymers being non-toxic and stable once ingested.

REFERENCES:
patent: 3308020 (1967-03-01), Wolf et al.
patent: 3383281 (1968-05-01), Wolf et al.
patent: 3787474 (1974-01-01), Daniels et al.
patent: 3803237 (1974-04-01), Lednicer et al.
patent: 3923972 (1975-12-01), Fields et al.
patent: 3953406 (1976-04-01), Marsh, Jr.
patent: 3980770 (1976-09-01), Ingelman et al.
patent: 4027009 (1977-05-01), Grier et al.
patent: 4071478 (1978-01-01), Shen et al.
patent: 4098726 (1978-07-01), Wagner et al.
patent: 4101461 (1978-07-01), Strop et al.
patent: 4111859 (1978-09-01), Strop et al.
patent: 4198396 (1980-04-01), Seidel et al.
patent: 4205064 (1980-05-01), Wagner et al.
patent: 4217429 (1980-08-01), Wagner et al.
patent: 4340585 (1982-07-01), Borzatta et al.
patent: 4412011 (1983-10-01), Kihara et al.
patent: 4540760 (1985-09-01), Harada et al.
patent: 4557930 (1985-12-01), Kihara et al.
patent: 4559391 (1985-12-01), Ueda et al.
patent: 4605701 (1986-08-01), Harada et al.
patent: 4680360 (1987-07-01), Ueda et al.
patent: 4759923 (1988-07-01), Buntin et al.
patent: 4777042 (1988-10-01), Toda et al.
patent: 4837015 (1989-06-01), Olsen
patent: 5055197 (1991-10-01), Albright et al.
patent: 5114709 (1992-05-01), St. Pierre et al.
patent: 5236701 (1993-08-01), St. Pierre et al.
patent: 5374422 (1994-12-01), St. Pierre et al.
patent: 5430110 (1995-07-01), Ahlers et al.
patent: 5451397 (1995-09-01), Albright et al.
H. Toda, et al., "Bile Acid Binding and Hypocholesterolemic Activity of a New Anion Exchange Resin from 2-Methylimidazol and Epichlorohydrin," J. Pharm. Sci., 77:531-33 (1988).
A. E. Heming and Thomas L. Flanagan, "Considerations in the Selection of Cation Exchange Resins for Therapeutic Use," Annals of The New York Academy of Sciences, 57;239-251 (1954).
N. S. Mason, et al., "A New Ion Exchanger with High in vivo Sodium Capacity," Kidney International, 28(17):S-178-S-182 (1985).

Affiliated with

Also associated with

Rating

Process for removing bile salts from a patient and compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for removing bile salts from a patient and compositions , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for removing bile salts from a patient and compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-706220