Process for removal of viruses from solutions of physiologically

Details Process for removal of viruses from solutions of physiologically Process for removal of viruses from solutions of physiologically

1991-01-14

1992-12-22

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435192, 435215, 435217, 530344, 530414, C12N 900, C12N 908, C12N 972, C07K 326

Patent

active

051734150

ABSTRACT:
A membrane filter of 0.025 to 0.05 .mu. in pore size is treated by passing the solution of a water-soluble high molecular substance such as albumin, dextran, polyvinylpyrrolidone, polysorbate 80, gelatin or the like through the membrane filter. Employing the filter thus treated, the solution of a physiologically active substance of human origin such as human growth hormone, kallikrein, trypsin inhibitor, epidermal growth factor, leucocyte interferon etc. is filtered at high recovery rate of the active substance avoiding the adsorption of the active substance onto the filter. By the filtration, harmful viruses such as Creutzfeldt-Jacob disease pathogen which may exist in the physiologically active substance can be removed.

REFERENCES:
patent: 4663227 (1987-05-01), Yamamori et al.
patent: 4711793 (1987-12-01), Ostreicher et al.
patent: 5076933 (1991-12-01), Glenn et al.
Cliver, "Factors in the Membrane Filtration of Enteroviruses", Applied Microbiology 13(3):417-425 (May 1965).
Maniatis et al., Molecular Cloning--A Laboratory Manual CSH 1982 pp. 325-326.
Bowen et al., Nucleic Acids Research vol. 8, #11980, pp. 1-20.

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