Process for removal of inorganic salts from peptide/salt-contain

Details Process for removal of inorganic salts from peptide/salt-contain Process for removal of inorganic salts from peptide/salt-contain

1977-10-03

1978-09-26

Sever, Frank

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

55 67, 55386, 73 231, 734215R, 210 31C, 210198C, 260112B, C07G 700

Patent

active

041169484

ABSTRACT:
The invention concerns a process for removing inorganic salts from a liquid medium having a solids content of from about 25 to about 65 mg/ml and containing active organic peptide substances of a molecular weight of from about 500 to about 10,000 and up to 70% by weight inorganic salts based on the solids content of the liquid medium, which comprises the steps of transferring said liquid medium onto a filtration gel layer carried on a perforated centrifuge drum at a liquid medium: gel volume ratio of from about 1:2.5 to about 1:4.5, said filtration gel layer being higher cross-linked and having a particle size of from about 40 to 120 .mu., centrifuging at a centrifugal force of from about 800 to about 1500 g, and collecting the liquid centrifugate containing the active organic peptide substances and a low amount of salt.
The substance recovered by the process possesses growth regulating properties and can be recovered from mammalian blood or serum.

REFERENCES:
patent: 3078647 (1963-02-01), Mosier
patent: 3856669 (1974-12-01), Ito et al.
"A Method for Concentrating Solutes of High Molecular Weight"; Flodin et al.; Nature; Nov. 5, 1960, pp. 493, 494.
"Solid Phase Peptide Synthesis"; W. H. Freeman & Co.; Pubrs; 1969; pp. 50-52.
"Trennung von Proteinen und Peptide"; Determann et al.; Wiley Interscience Publn; vol. II, pp. 1052-1058; Chem Abs.; vol. 72, 1970, art No. 129360h.

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