Process for reductively aminating ketones and aldehydes with...

Details Process for reductively aminating ketones and aldehydes with... Process for reductively aminating ketones and aldehydes with...

2008-01-29

2008-01-29

Barts, Samuel A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

11526337

ABSTRACT:
A process for preparing amines of the general formula (I)in-line-formulae description="In-line Formulae" end="lead"?R1R2CHNR3R4  (I)in-line-formulae description="In-line Formulae" end="tail"?in which R1, R2, R3and R4are each independently hydrogen, straight-chain or branched, halogenated or halogen-free C1-C12-alkyl, C3-C12-cycloalkyl, C6-C10-aryl or C7-C11-aralkyl, by catalytic, hydrogenating amination of carbonyl compounds of the general formula (II)in-line-formulae description="In-line Formulae" end="lead"?R1—C(═O)—R2  (II)in-line-formulae description="In-line Formulae" end="tail"?with nitrogen compounds of the general formula (III)in-line-formulae description="In-line Formulae" end="lead"?HNR3R4  (III)in-line-formulae description="In-line Formulae" end="tail"?in the presence of bifunctional catalyst systems comprising a.) a hydrogenation-active catalyst component comprising one or more metals of transition group 8 of the Periodic Table and b.) one or more solid, acidic cocatalysts, wherein the hydrogenating amination is carried out in the presence of aqueous ammonia or aqueous amine of the formula (III) and at least one organic solvent miscible with ammonia or the aqueous amine of the formula (III).

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EPO Office Action for Corresponding Application No. 06019315.8 dated Dec. 27, 2006.

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