Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Patent
1993-11-18
1995-05-23
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
424 7817, 424423, 424 781, 522126, 528488, 422 22, A61L 208, A61L 1700, A61L 2700
Patent
active
054179696
ABSTRACT:
Processes for forming a uniform, continuous coating of heparin covalently bonded to blood-contacting polyvinylchloride surfaces of a medical device are disclosed. These processes include coating the polyvinylchloride surfaces with an organic solvent solution of heparin complexed with an organic cation, and then exposing the coated surfaces to ionizing radiation to covalently bind the heparin moiety to the polyvinylchloride. The complex of the coating is formed from a heparin moiety and at least one cationic moiety selected from the group consisting of dimethylstearylamine, polyethyleneimine, benzalkonium, stearylkonium, and tridodecylmethylammonium; the complex is soluble in organic solvents and forms continuous and uniform coatings on polyvinylchloride. Advantageously, the heparin moiety can be bonded to the polyvinylchloride surfaces simultaneously with sterilizing the medical devices using ionizing radiation.
REFERENCES:
patent: 3453194 (1969-07-01), Bennett et al.
patent: 3625745 (1971-12-01), Wright et al.
patent: 4094756 (1978-06-01), Taylor
patent: 4656083 (1987-04-01), Hoffman et al.
patent: 4871357 (1989-10-01), Hsu et al.
patent: 4927676 (1990-05-01), Williams et al.
Chawla et al. Pharmacology 20:224-228 1980.
Balding David P.
Farhat Lawrence
Hsu Li-Chien
Baxter International Inc.
Kulkosky Peter F.
Page Thurman K.
Sun Raymond
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