Process for reducing the incidence of neonatal diarrhoea in pigs

Details Process for reducing the incidence of neonatal diarrhoea in pigs Process for reducing the incidence of neonatal diarrhoea in pigs

1977-05-06

1979-01-23

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, A61K 3902, A61K 3940

Patent

active

041361679

ABSTRACT:
A vaccine comprising an antigen selectively adsorbed onto erythrocytes possessing their natural surface characteristics. When the antigen is the K88a,b/adhesion factor of E. coli and the erythrocytes are chicken erythrocytes, the vaccine is especially suitable for reducing the incidence of neonatal diarrhoea in pigs if it is administered parenterally to a sow about three weeks prior to parturition.

REFERENCES:
Jones et al., J. Gen. Microbiol. 84(1): 135-144, Jan.-Feb. 1974, "The Association of K88 Antigen with Haemagglutinating Activity in Porcine Strains of E. Coli".
Rutter et al., Vet. Bull. 43(8), #3222, Aug. 1973 of Nature 242(5399): 531-532 (1973).
Jones et al., Vet. Bull. 45(11), #6067, Nov. 1975 of Am. J. Clin. Nutr. 27(12): 1441-1449 (1974).
Rutter et al., Vet. Bull. 45(7), #3645, Jul. 1975 of Vet. Rec. 96(8): 171-175 (1975).
Neter et al., J. Bacteriol. 66: 424-428 (1953), "The Requirement of Electrolytes for the Adsorption of Eschorichia Coli Antigen by Red Blood Cells" as abstracted in Chem. Abstracts 48 #855e (1954).
Kabat et al., Experimental Immunochemistry, 2nd ed. (1961), C. C. Thomas, Springfield, Il., p. 97, "Agglutination", 119-124, Adsorption of Antigens on Untreated Erthyrocytos--Coupling of Antigens to Erthrocytes.

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