Process for reducing pathogens in a biological sample and...

Details Process for reducing pathogens in a biological sample and... Process for reducing pathogens in a biological sample and...

2008-07-29

2008-07-29

Beisner, William H (Department: 1797)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

C435S268000, C435S308100, C436S175000, C436S177000

Reexamination Certificate

active

10900061

ABSTRACT:
The present invention is directed towards an apparatus and method for disinfecting biological samples, including semen and the like, and for removing a biological sample pellet from surrounding media while reducing the risk of recontamination of the pellet with said media. An insert receptacle includes a receiving cylinder having a drain in a floor which allows the fluids to decant slowly down the side of a tube. The insert receptacle further includes an aspiration channel which allows an aspiration device, such as a modified micro-pipette, to be utilized for extracting a sample pellet from the bottom of the tube. Utilizing the novel apparatus, a method for reducing pathogens in a biological sample includes decanting the biological sample through the receiving cylinder and into a tube where it passes through a multi-layer gradient including an enzyme suitable for removal of at least one pathogen from the biological sample. Centrifuging of the insert receptacle, tube, and sample, isolates a sample pellet of the biological sample from the surrounding at least one pathogen. After the sample pellet is isolated it is aspirated via the aspiration device without re-contaminating the sample pellet through contact with the surrounding at least one pathogen.

REFERENCES:
patent: 4435293 (1984-03-01), Graham et al.
patent: 5681709 (1997-10-01), Mochnal et al.
patent: 2002/0185457 (2002-12-01), Smith et al.
patent: 2005/0079480 (2005-04-01), Loskutoff
patent: WO 02094739 (2002-11-01), None

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