Process for reducing contaminating Michael acceptor levels...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S045000

Reexamination Certificate

active

07875623

ABSTRACT:
The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.

REFERENCES:
patent: 2005/0222188 (2005-10-01), Chapman et al.
patent: 2006/0173029 (2006-08-01), Chapman et al.
Brogle, et al., “Peak fronting in reversed-phase high-performance liquid chromatogrphy: a study of the chromatographic behavior of oxycodone hydrochloride,”Journal of Pharmaceutical and Biomedical Analysis, vol. 19, pp. 669-678 (1999).

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