Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Bacterium or component thereof or substance produced by said...
Patent
1974-04-24
1979-04-03
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
Bacterium or component thereof or substance produced by said...
2603405R, A61K 3136
Patent
active
041477995
ABSTRACT:
Ethanolamine derivatives and their acid addition salts are prepared (1) by reacting a 1-(3,4-methylenedioxyphenyl)-2-aminoethanol compound or an .alpha.-amino-(3,4-methylenedioxy)acetophenone compound with an alkanal or an alkanone under reduction conditions, (2) by hydrogenating and/or hydrogenolyzing a 1-(3,4-methylenedioxyphenyl)-2-(N-substituted amino)-ethanol compound or an .alpha.-(N-substituted amino)-(3,4-methylenedioxy)acetophenone compound, and (3) by reacting a (3,4-methylenedioxyphenyl)-ethylene oxide compound or a 1-(3,4-methylenedioxyphenyl)-2-substituted ethanol compound with an amine. The ethanolamine derivatives and their salts show .beta.-adrenergic receptor blocking activity, and are expected to be useful in the treatment of heart disease, hypertension, myocardites and pheochromocytoma.
REFERENCES:
patent: 1073966 (1913-09-01), Decker
patent: 1964973 (1934-07-01), Bockmuhl et al.
patent: 2011454 (1935-08-01), Nagai
patent: 3657244 (1972-04-01), Mentrup et al.
Kasuya Yutaka
Obase Hiroyuki
Fagelson Anna P.
Kyowa Hakko Kogyo Co. Ltd.
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