Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Reexamination Certificate
2006-09-19
2006-09-19
Witz, Jean C. (Department: 1651)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
C435S135000, C435S138000, C435S189000
Reexamination Certificate
active
07109004
ABSTRACT:
A process for preparing (R)-hydroxy ester (II)from alpha-keto ester Icomprising adding the alpha-keto ester I to a mixture comprising the ketoreductase enzyme and non-ketoreductase enzyme components, wherein the ketoreductase enzyme has a molecular weight between 36000 and 38000, and wherein the ketoreductase enzyme has an N-terminal amino acid sequence selected from the group of sequences consisting of(SEQ. ID NO. 1)Ala-Ile-Pro-Asp-Asn-Ala-Val-Leu-Glu-Gly-Ser-Leu-Val-Lys-Val-Thr-Gly-Ala-Asn-Gly(SEQ. ID NO. 4)Met-Ala-Ile-Pro-Asp-Asn-Ala-Val-Leu-Glu-Gly-Ser-Leu-Val-Lys-Val-Thr-Gly-Ala-Asn-Gly, and(SEQ. ID NO. 2)Met-Ala-Lys-Ile-Asp-Asn-Ala-Val-Leu-Pro-Glu-Gly-Ser-Leu-Val-Leu-Val-Thr-Gly-Ala-Asn-Gly.
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Kim Jaehon
McLaughlin Kathleen
Moore Jeffrey C.
Sturr Michael G.
Camara Valerie J.
Hanley Susan
Merck & Co. , Inc.
Parr Richard S.
Witz Jean C.
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