Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1993-03-12
1995-07-18
Prescott, Arthur C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
210659, B01D 1508, C07B 5700
Patent
active
054342988
DESCRIPTION:
BRIEF SUMMARY
FIELD OF INDUSTRIAL APPLICATION
The present invention relates to a process for recovering optical isomers and a solvent, a process for using the solvent by circulation and a process for reusing the optical isomers. In particular, the present invention relates to a process for recovering optical isomers and a solvent, wherein the optical isomers can be efficiently separated from each other and the solvent used for the optical resolution can be efficiently recovered, a process for using the solvent by circulation, wherein the solvent recovered by the recovering process of the present invention is reused for the effective utilization of the solvent, and a process for reusing the optical isomers, wherein the intended optical isomers obtained by the optical resolution are reused without being discarded so as to further improve the efficiency of the optical resolution.
PRIOR ART
It is well known that optical isomers have different effects on the living body, though they are chemically the same. Therefore, it is an extremely important problem in the industrial fields of medicines, pharmacy, biochemistry, etc., to prepare an optically pure compound in order to improve the efficacy of the medicine per unit quantity and to prevent drug-induced sufferings caused by adverse reactions of the drug. For the separation of such an optical isomer mixture, i.e., optical resolution of them, a diastereomer method, crystallization method, enzyme method, separating membrane method or the like has been employed heretofore. However, such a method is generally unsuitable, since the kinds of the compounds which can be optically resolved are usually limited. Although chromatography can be employed for the optical resolution, the chromatographic methods known at present are of a batch type and hence cannot avoid discontinuous and unstationary operations, which is unsuitable for the mass processing. Further, this chromatographic method has another defect in that since a large amount of an eluent is necessitated and the concentration of the intended compound in the eluate is low, much energy and complicated steps are necessitated for the recovery.
An object of the present invention is to provide a novel process which can separate optical isomers and a solvent efficiently from a large amount of a mixture comprising the optical isomers. Another object of the present invention is to provide a process for efficiently separating each of optical isomers and a solvent from a large amount of a mixture comprising the optical isomers and also reusing the recovered solvent.
DISCLOSURE OF THE INVENTION
The invention which solves the above problem relates to a process for recovering optical isomers and a solvent in optical resolution by introducing a liquid containing an optical isomer mixture and an eluent into a packed bed containing packings for optical resolution, having both ends connected to each other through a fluid passage to be endless and circulating the liquids therein by one-way flow, and simultaneously recovering a liquid containing one optical isomer and a liquid containing the other optical isomer which are separated from the packed bed, characterized by arranging an inlet for the eluent, an outlet for a liquid (extract) containing an easily adsorbable optical isomer, an inlet for the liquid containing an optical isomer mixture, and an outlet for a liquid (raffinate) containing a difficulty adsorbable optical isomer in this order in the direction of liquid flow onto the packed bed, and recovering the solvent and optical isomers from the extract and/or raffinate thus obtained with a simulated moving bed system such that the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the bed.
Further, the invention relates to the above mentioned process for recovering optical isomers and a solvent, wherein the packing for optical resolution has a particle diameter of 1 to 100 .mu.m,
the invention relates to the above mentioned process for recovering optical isomers and a solvent in optical
REFERENCES:
patent: 2985589 (1961-05-01), Broughton et al.
patent: 4842935 (1989-06-01), Shinbo et al.
patent: 5126055 (1992-06-01), Yamashita et al.
patent: 5220053 (1993-06-01), Choudhury et al.
UOP Sorbex Process, Nikki Universal Co., Ltd., pp. 1-7, Oct. 1989.
Negawa Masakazu
Shoji Fumihiko
Daicel Chemical Industries Ltd.
Prescott Arthur C.
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