Process for recombinant expression and purification of...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide

Reexamination Certificate

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C424S009100, C424S009200, C424S093200, C424S184100, C424S200100, C424S234100, C424S278100, C424S282100, C435S041000, C435S069800

Reexamination Certificate

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07579005

ABSTRACT:
A process was developed for expressing antimicrobial peptides in a recombinant host cell that eliminates host cell toxicity and antimicrobial peptide degradation, as well as providing a process for rapid purification. Fusion proteins comprising a periplasmic targeting signal, cleavage site, and antimicrobial peptides provide the basis for this process which produces antimicrobial peptides that may be used in antimicrobial compositions and articles.

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