Process for racemizing certain spiro compounds

Details Process for racemizing certain spiro compounds Process for racemizing certain spiro compounds

1984-03-26

1986-01-28

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548410, C07D48710

Patent

active

045672784

ABSTRACT:
The invention concerns a novel process for the racemisation of unwanted enantiomeric forms of 1'-substituted spiro[imidazolidine-4,3'-indoline]-2,2',5-triones and 1'-substituted spiro[pyrrolidine-3,3'-indoline]-2,2',5-triones which comprises heating an unwanted enantiomeric form (or a mixture containing an excess of one enantiomer over the other) alone or, more conveniently, in the presence of a solvent or diluent at a temperature in the range 80.degree. to 280.degree. C.

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Gilman, H., et al. (Editors), Organic Chemistry, John Wiley, New York, 1938, pp. 176-177.
Gilman, H., et al. (Editors), Organic Chemistry, Second Edition, John Wiley, New York, 1943, pp. 241-248.
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T. Fukumura, et al., FEBS Letters, 1978, 89 (2), 298-300.
I. Z. Siemon, et al., Z. fur Naturforeschung, 1971, 26, 762-764.
V du Vigneaud, et al., J. Biol. Chem., 1932, 99, 143.

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