Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2005-01-25
2005-01-25
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S164000, C564S165000, C564S198000
Reexamination Certificate
active
06846955
ABSTRACT:
The invention relates to a process for racemising an enantiomer-enriched Schiff base of a primary amino acid amide with a strong base that is chemically reactive towards water. The reaction is conducted in an organic solvent. Preferably a metal alkoxide, a metal alkyl, a metal amide, or a metal hydride, in particular a metal alkoxide is applied as the strong base. As the Schiff base preferably N-benzylidene primary amino acid amide is used, with the primary amino acid amide preferably being derived from an aliphatic primary amino acid amide, for example tertiary-leucine amide. As organic solvent use is preferably made of an aromatic hydrocarbon, a cyclic, aliphatic hydrocarbon or a ether, in particular an aromatic hydrocarbon is applied. The invention may also be applied for the racemisation of an enantiomer-enriched primary amino acid amide.
REFERENCES:
patent: 4172846 (1979-10-01), Boesten
patent: 4847412 (1989-07-01), Boesten et al.
patent: 5679857 (1997-10-01), Hijiya et al.
patent: 716062 (1996-06-01), None
Database WPI Section Ch, week 198607 Derwent Publications Ltd., London, GB; AN 1986-046542 XP 002160541 & JP 61 001652 A (Nissan Chem Ind Ltd.), Jan. 7, 1986.
de Bode Ronus
Hermsen Petrus Johannes
Hof Robert Patrick
DSM N.V.
Kumar Shailendra
Morrison & Foerster / LLP
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