Process for R (+) ne, a central nervous system agent

Details Process for R (+) ne, a central nervous system agent Process for R (+) ne, a central nervous system agent

1994-09-12

1998-01-20

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 59, 562459, C07D21102, C07C 6976, C07C 6532

Patent

active

057102775

ABSTRACT:
An improved process for the preparation of dine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboylic acid or .alpha.-chymotrypsin to selectively hydrolyze n-butyl 5-oxo-3-phenyl-3-cycohexenecarboxylate to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes.

REFERENCES:
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Journal of Medicinal Chemistry, vol. 37, No. 21, pp. 3523-3533 (1994), Wright et al.
Johnson, S.J., et al., 206th National Meeting, American Chemical Society, Chicago, Illinois, Aug. 1993, MEDI-171.
Tetrahedron Letters, vol. 35, No. 1 pp. 61-64 (1994), Wustrow, D.J., et al.
Wright, J., et al., 206th National Meeting, American Chemical Society, Chicago, Illinois, Aug. 1993, MEDI-22.
Downing, D.M., et al., 208th National Meeting American Chemical Society, Washington, D.c., Aug. 1994, MEDI-178.
Downing, D.M., et al., 206th National Meeting American Chemical Society, Chicago, Illinois, Aug. 1993, MEDI-173.
Wise, L.D., et al., 208th National Meeting American Chemical Society, Washington, D.C., Aug. 1994, MEDI-266.

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