Process for purifying particles of biological origin, particular

Details Process for purifying particles of biological origin, particular Process for purifying particles of biological origin, particular

1980-12-05

1982-06-15

Castel, Benoit

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Recovery or purification

260112B, 424 89, 210787, 210805, A61K 3912, C12K 700

Patent

active

043352146

ABSTRACT:
The invention relates to a process for purifying biological particles, particularly for purifying the surface antigen (HBs) of the hepatitis B virus. A suspension of this HBs antigen is subjected to rate zonal banding in a gradient inside a centrifuge equipped with a continuous-flow core. At the same time as the centrifugation operation is carried out, the suspension of particles to be purified is caused to circulate in a closed circuit in which the centrifuge is inserted. The band containing the purified biological particles is then collected in a way known per se.

REFERENCES:
patent: 3838144 (1974-09-01), Leach
patent: 3951937 (1976-04-01), Vnek et al.
patent: 4024243 (1977-05-01), McAleer et al.
patent: 4088748 (1978-05-01), McAleer et al.
patent: 4102996 (1978-07-01), McAleer et al.
patent: 4217418 (1980-08-01), McAleer et al.

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