Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-06-14
2011-06-14
McIntosh, III, Traviss C (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07960542
ABSTRACT:
A process for the purification of an oligonucleotide synthon is provided. The process comprises subjecting an organic solution comprising an oligonucleotide synthon and lower molecular weight impurities to nanofiltration whereby the ratio of an oligonucleotide synthon to lower molecular weight impurities in the solution is increased after the nanofiltration. Preferably, the oligonucleotide synthon is a nucleoside phosphoramidite or nucleoside H-phosphonate. The nanofiltration membrane is preferably a polyimide membrane having a molecular weight cut off of 400.
REFERENCES:
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 5026838 (1991-06-01), Nojiri et al.
patent: 98/15581 (1998-04-01), None
patent: WO98/15581 (1998-04-01), None
patent: 03/087130 (2003-10-01), None
Stawinski et al: “Nucleoside H-phosphonates. 12. Synthesis of nucleoside 3′-(hydrogen-phosphonothioate) monoesters via phosphinate intermediates” Journal of Organic Chemistry, American Chemical Society. Easton, US, No. 55, 1990, pp. 3503-3506, XP002075156 ISSN: 0022-3263 p. 3505.
Bhongle N N et al: “A Convenient Synthesis of Nucleoside 3′-H-Phosphonate Monoesters Using Triphosgene” Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 36, No. 38, Sep. 18, 1995, pp. 6803-6806, XP004027390 ISSN: 0040-4039 p. 6804, line 15-19.
Ozola V et al: “Use of Ammonium Aryl H-Phosphonates in the Preparation of Nucleoside H-Phosphonate Building Blocks” Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 37, No. 47, Nov. 18, 1996, pp. 8621-8624, XP004068732 ISSN: 0040-4039 p. 8623.
Boam Andrew Timothy
Hargreaves Stephen
Livingston Andrew Guy
McCormac Paul
Nair Dinesh
Avecia Biotechnology Inc.
McIntosh, III Traviss C
Tinkler Timothy E.
LandOfFree
Process for purifying oligonucleotide synthons does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for purifying oligonucleotide synthons, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for purifying oligonucleotide synthons will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2681773