Process for purifying iodinated bile acid conjugates

Details Process for purifying iodinated bile acid conjugates Process for purifying iodinated bile acid conjugates

1977-06-13

1980-06-10

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

2603971, 26023957, 260112R, 424106, 424242, A61K 2900, A61K 4300

Patent

active

042073081

ABSTRACT:
Iodinatable bile salt derivatives are obtained by providing bile salts and their glycine and taurine conjugates with iodinatable groups. The radioiodinated compounds are useful in the radioimmunoassay of bile salts and in physiological studies. The preferred compound is cholylglycylhistamine. The synthesis of radioiodinated conjugates and their purification by extraction and silica gel chromatography are described.

REFERENCES:
patent: 3855208 (1974-12-01), Rutner et al.
Demers et al., Clin. Chem., vol. 22, No. 5, May 1976, pp. 602-606.
Spenney et al., Gastroenterology, vol. 69, p. A68/868, Sep. 23, 1975.
Bolton et al., Biochem. J., vol. 133, 1973, pp. 529-539.
Spenney et al., Gastroenterology, vol. 72, No. 2, 1977, pp. 305-311.

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