Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Reexamination Certificate
2011-03-08
2011-03-08
Landsman, Robert (Department: 1646)
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
C530S351000, C530S412000, C530S413000
Reexamination Certificate
active
07901670
ABSTRACT:
Provided is a process for purifying human interferon beta from a recombinant human interferon beta-containing culture comprising performing affinity chromatography and cation exchange chromatography, wherein the affinity chromatography includes: adsorbing the interferon beta-containing culture to an equilibrated affinity chromatography column, followed by washing with an equilibration buffer solution; washing the column with a washing buffer solution A of pH 6.5-7.5 containing 30-60 wt % of propylene glycol and a washing buffer solution B of pH 6.5-7.5 containing 10-30 wt % of propylene glycol and 1-2M NaCl; and eluting a human interferon beta-containing fraction with a buffer solution of pH 6.5-7.5 containing 40-60 wt % of propylene glycol and 1-2M NaCl.
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Ahn Jee Won
Baek Min Ji
Chung Jong Sang
Kim Ki Wan
Lee Dong Eok
CJ Cheiljedang Corporation
Hissong Bruce D
Landsman Robert
Rothwell, Figg Ernst & Manbeck, PC
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