Process for purifying hepatitis a virus (HAV), and vaccine compo

Details Process for purifying hepatitis a virus (HAV), and vaccine compo Process for purifying hepatitis a virus (HAV), and vaccine compo

1994-07-18

1997-03-04

Smith, Lynette F.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4352351, 4241891, 4242261, 530412, 530355, 530416, C12N 704, C12N 701, A23J 100, A61K 3900

Patent

active

056078510

ABSTRACT:
A process is described for the purification of the hepatitis A virus, which allows one to obtain with good yields a pure product, in which organic material collected by centrifugation after lysis of the culture cells is submitted to gel filtration and successively to ion exchange chromatography.

REFERENCES:
patent: 4624918 (1986-11-01), Herschberg
patent: 4673634 (1987-06-01), Seto
patent: 4744983 (1988-05-01), Morein
patent: 5004688 (1991-04-01), Craig et al.
patent: 5011915 (1991-04-01), Yamazaki
patent: 5151023 (1992-09-01), Kuzuhara
Flehmig et al, 1989, "Immunogenicity of a Killed hepatitis A . . . " Lancet, May 13, 1989 pp. 1039-1041.

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