Process for purifying fructose 1,6-diphosphate

Details Process for purifying fructose 1,6-diphosphate Process for purifying fructose 1,6-diphosphate

1993-03-26

1995-07-18

Redding, David A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536127, C07H 1104, C07H 1300, C07H 106

Patent

active

054342554

ABSTRACT:
A process for the purification of fructose 1,6-diphosphate which comprises subjecting a fructose 1,6-diphosphate-containing solution to anion exchange column chromatography to separate fructose 1,6-diphosphate therefrom, and subsequently subjecting the resulting FDP fraction to a desalting treatment, so as to provide a highly purified FDP preparation useful as a pharmaceutical drug and the like in a high yield.

REFERENCES:
patent: 4530902 (1985-07-01), Perri et al.
patent: 4575549 (1986-03-01), Diana et al.
patent: 4787940 (1988-11-01), Kayane et al.
patent: 4920049 (1990-04-01), Bisso et al.
patent: 5094947 (1992-03-01), Nakajima et al.
"Fructose-1, 6-Diphosphoric acid and Fructose-6-Monophosphoric Acid", C. Neuberg et al. Arch Biochem, vol. 3, pp. 33-44, 1943.
"Methods of Enzymatic Analysis" Third Edition, vol. 6, pp. 191-199 and pp. 342-351.

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