Process for purifying cephalosporin compounds

Details Process for purifying cephalosporin compounds Process for purifying cephalosporin compounds

1982-06-15

1984-02-07

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50104

Patent

active

044305001

ABSTRACT:
A cephalosporin compound of the formula: ##STR1## wherein X is hydrogen, halogen, hydroxy, alkyloxy, aralkyloxy, aryloxy, mercapto, alkylthio, aralkylthio, arylthio, alkylsulfonyl, aralkylsulfonyl, arylsulfonyl, alkylsulfinyl, aralkylsulfinyl, arylsulfinyl, amino, mono-or di-alkylamino, mono- or di-aralkylamino, mono- or di-arylamino, acylamino, a sulfonic acid group, nitro, alkyl, aralkyl, aryl or a heterocyclic group; R is hydrogen, alkyl, aralkyl, aryl or a heterocyclic group, with all of the alkyl, aralkyl, aryl and heterocyclic ring groups in radicals X and R optionally being substituted with at least one substituent, is purified by (a) adjusting the pH of an aqueous solution containing said cephalosporin compound to be purified to within the range of 1.0 to 3.5; (b) isolating the compound which precipitates from said solution; (c) after concentration adding the resulting mother liquor to the organic solvent, isolating the precipitated compound and agitating the obtained compound in an aqueous solution in the presence of an absorbing resin which is a hydrophilic, high molecular weight material having a fine network structure; and (d) isolating the purified compound.

REFERENCES:
patent: 4217450 (1980-08-01), Yasuda et al.

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