Process for purifying and characterizing myotrophia, a novel pep

Details Process for purifying and characterizing myotrophia, a novel pep Process for purifying and characterizing myotrophia, a novel pep

1990-09-07

1994-02-08

Griffin, Ronald W.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530329, 530330, C07K 700

Patent

active

052849325

ABSTRACT:
The present invention is directed to a process for purifying and characterizing "myotrophin", a novel soluble protein factor that is believed to regulate myocardial hypertrophy in hypertension. In addition, the invention is directed to the purified and partially characterized protein factor produced by the process of the present invention, as well as uses of this factor, or its antagonist to control cardiac hypertrophy.

REFERENCES:
Sen et al., J. Biol Chem., vol. 265(27), 1990, pp. 16635-16643.
Trezise et al., Proc. Natl. Acad. Sci USA, vol. 86, 1989, pp. 5454-5458.
Heden et al., FEBS Lett., vol. 194, 1986, pp. 327-332.

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