Process for purifying...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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C436S098000

Reexamination Certificate

active

06852858

ABSTRACT:
Zaleplon can be separated from a regioisomer impurity by crystallization from selected solvents or by adding an anti-solvent to a solution of zaleplon and the regioisomer. Zaleplon crystalline Forms II, III, IV, and V are useful for the treatment of insomnia. These crystalline Forms are described along with processes for making them v crystallization from selected solvents.

REFERENCES:
patent: 4626538 (1986-12-01), Dusza
patent: 5714607 (1998-02-01), Padmanathan
patent: WO 200212244 (2002-02-01), None
Mustazza, J. Het. Chem. 38, 1119 (2001).

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