Process for purification of 1,2-bis(nicotinamido)propane

Details Process for purification of 1,2-bis(nicotinamido)propane Process for purification of 1,2-bis(nicotinamido)propane

1989-12-27

1992-03-24

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21344

Patent

active

050990225

ABSTRACT:
A novel process for purifying crude 1,2-bis(nicotinamido)propane obtained by the reaction of nicotinic acid with 1,2-propanediamine. This process comprises forming 1,2-bis(nicotinamido)propane dinitrate from the crude 1,2-bis(nicotinamido)propane, suspending the dinitrate in an organic solvent, adding an alkali or an alkaline solution to the suspension to dissociate the free 1,2-bis(nicotinamido)propane, extracting it from the suspension with a solvent, and removing the solvent to isolate the purified product.
According to this process, crude 1,2-bis(nicotinamido)propane can be efficiently purified to give the product having a high purity.

REFERENCES:
patent: 4366161 (1982-12-01), Mori et al.
patent: 4910301 (1990-03-01), Kaplan et al.

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