Process for providing a 6-ketone from morphine or an ether deriv

Details Process for providing a 6-ketone from morphine or an ether deriv Process for providing a 6-ketone from morphine or an ether deriv

1994-01-19

1995-02-07

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435119, C12P 1718, C12P 726

Patent

active

053875150

ABSTRACT:
Two enzymes, one an acetylmorphine carboxyesterase (AMCE), the other a morphine dehydrogenase (MDH), have been isolated from bacteria. The AMCE degrades heroin to morphine and the MDH oxidizes morphine to morphinone, with the aid of a cofactor. More particularly, the invention pertains to a process for preparing a 6-ketone from morphine or a methyl or ethyl derivative thereof. The process comprises oxidizing morphine or an ether derivative in the presence of a morphine dehydrogenase and the cofactor NADP.sup.+. These reactions are used in detection of heroin (using the two reactions coupled together) or morphine. The enzymes can be incorporated in sensors for this purpose.

REFERENCES:
patent: 4204044 (1980-05-01), Suhara et al.
patent: 4916069 (1990-04-01), Fujiwara et al.
patent: 4927759 (1990-05-01), Schofield et al.
J. of Biol. Chem., vol. 260, No. 9, pp. 5265-5270, Yamano et al (1985).
R. Ammon et al, Chemical Abstracts, vol. 100 (3) No. 17087q (1984).
F. Crespi et al, Chemical Abstracts, vol. 110 (5) No. 33279r (1989).
J. A. Owen et al, Chemical Abstracts, vol. 99 (18) No. 151702a (1983).
D. A. Smith et al, Chemical Abstracts, vol. 85 (3) No. 13602c (1976).
P. Liras et al, Chemical Abstracts, vol. 84 (5) No. 27348r (1976).
V. Jhaveri. Chemical Abstracts, vol. 89 (3) No. 18999c (1978).

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