Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-08-20
1989-05-30
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31495
Patent
active
048351555
ABSTRACT:
A process for protection of brain cells comprises orally or parenterally administering into a man suffering from ischemia or being susceptable to ischemia a piperazine derivative having the formula: ##STR1## wherein R.sup.1 is hydrogen or a lower alkyl group, R.sup.2 is hydroxyl, an aralkyloxy group, a lower alkoxy group having 1-5 carbon atoms or a lower alkenyloxy group having 3-5 carbon atoms, R.sup.3 is hydrogen, an aralkyloxy group, a lower alkoxy group having 1-5 carbon atoms or a lower alkenyloxy group having 3-5 carbon atoms and R.sup.4 is hydrogen or a lower alkoxy group having 1-5 carbon atoms.
REFERENCES:
patent: 4528194 (1985-07-01), Masaki
Delayed Neuronal Death in the Gerbil Hippocampus Following Ischemia, Brian Research, Kirino, 1982, vol. 239, pp. 57-69.
Selective Vulnerability of the Hippocampus to Ischemic, Progress in Brain Research, Kirino et al., vol. 63, pp. 39-58.
Chemical Abstracts, vol. 99, 1983, p. 622.
Kogure Kyuya
Masaki Mitsuo
Ferguson Jr. Gerald J.
Friedman Stanley J.
Nippon Chemiphar Co., Ltd.
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