Process for prophylaxis and therapy of thrombotic processes...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S001110, C536S021000, C536S123100, C536S124000

Reexamination Certificate

active

07008933

ABSTRACT:
A process for prophylaxis and therapy of thrombotic processes includes preparing heparin having an average molecular weight ranging from 10 to 11.5 kd; formulating a pharmaceutical preparation which includes the heparin; and employing the pharmaceutical preparation for prophylaxis and therapy of thrombotic processes. Preferably the heparin has an average molecular weight of 10.5 kd.

REFERENCES:
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Alban et al., “The Anticoagulatory Impact of Low-Molecular-Weight Heparins is Subject to Product-specific Endogenous Modulation. The Significance of TFPI Release and Profibrinalytic Effect”, American Congress of Cardiology, Orlando, Florida 1997.
Fareed et al., “Low molecular weight heparins: a development perspective”, Abstract, Ashley Publications Ltd., ISSN 1354-3783—1997.
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WO 01 02443—“Heparin Compositions That Inhibit Clot Associated Coagulation Factors”, Jack Hirsh, Publication date: Jan. 11, 2001.
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Kaiser et al., “Preclinical Biochemistry and Pharmacology of Low Molecular Weight Heparins in Vivo-Studies of Venous and Arterial Thrombosis”, Seminars in Thrombosis and Hemostasis, vol. 25, Suppl 3, (1999), pp. 35-42.
Alban et al., “Plasma Levels of total and Free Tissue Factor Pathway Inhibitor (TFPI) as Individual Pharmacological Parameters of Various Heparins”, Thromb Haemost 2001; 85; pp. 824-829.
GLYCODesign, Inc., Pharmaceutical and Biotechnology Companies, NetSci: The Biotech Yellow Pages, Seite 1, von 2, glycodesign.html.

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