Process for production of radioactive fluorine-labeled...

Details Process for production of radioactive fluorine-labeled... Process for production of radioactive fluorine-labeled...

2011-03-01

2011-03-01

Zucker, Paul A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

07897811

ABSTRACT:
A process is provided for producing [18F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for producing a radioactive fluorine-labeled organic compound, including a deesterification step of retaining, in a reverse-phase column, a compound represented by Formula (1):wherein R1is a linear or branched C1-C10-alkyl chain or an aromatic substituent, and R2is a protecting group;charging the column with an alkaline solution to deesterify the compound, and subsequently discharging the alkaline solution from the column to obtain a compound represented by Formula (2):wherein X is sodium or potassium; anda deprotection step of deprotecting the amino-protecting group of the compound obtained in the deesterification step to obtain a compound represented by Formula (3):

REFERENCES:
patent: 2006/0039855 (2006-02-01), Gibson et al.
patent: 2007/0036258 (2007-02-01), Ito et al.
patent: 2006-510706 (2006-03-01), None
patent: WO2004/056725 (2004-07-01), None
patent: WO2005/030677 (2005-04-01), None
PCT International Preliminary Report on Patentability in PCT/JP2007/059459, dated Dec. 10, 2008.
PCT Written Opinion of the International Searching Authority in PCT/JP2007/069459.

Affiliated with

Also associated with

Rating

Process for production of radioactive fluorine-labeled... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for production of radioactive fluorine-labeled..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for production of radioactive fluorine-labeled... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2644283