Process for production of R-phenylacetylcarbinol by an...

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

Reexamination Certificate

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C568S312000, C568S336000, C564S305000

Reexamination Certificate

active

07074966

ABSTRACT:
This application relates to a new process for the production of R-phenylacetylcarbinol by an enzymatic process in a liquid two-phase system.

REFERENCES:
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patent: WO 96/37620 (1996-11-01), None
patent: WO 99/09195 (1999-02-01), None
patent: WO 99/63103 (1999-12-01), None
Nikolova, P., et al., “Production of Phenylacetyl Carbinol by Biotransformation Using Baker's Yeast in Two-Phase Systems,”Progress in Biotechnology, 8:675-680 (1992).
Nikolova, P., et al., “Whole Cell Yeast Biotransformations in Two-Phase Systems: Effect of Solvent on Product Formation and Cell Structure,”Journal of Industrial Microbilogy, 10(3-4):169-177 (1992).
Oliver, Alison L., et al., “Factors Affecting the Productiono f L-Phenylacetylcarbinol by Yeast: A Case Study,”Advances in Microbial Physiology, 41:1-45 (1999).
Ward, Owen P., et al., “Enzymatic Asymmetric Synthesis by Decarboxylases,”Current Opinion in Biotechnology, 11(6):520-526 (2000).
Dornemann, S., et al., “Stereospecific Formation of R-Aromatic Acyloins by Zymomonas Mobilis Pyruvate Decarboxylase,”Journal of the Chemical Society, Perkin Transactions, 1(5):425-430 (1996).
Rosche, Bettina, et al., “Enhanced Production of R-Phenylacetylcarbinol (R-PAC) Through Enzymatic Biotransformation,”Journal of Molecular Catalysis B: Enzymatic, 10(20):109-115 (2002).
Shin, Hyoun S., et al., Production of L-Phenylacetylcarbinol (L-PAC) from Benzaldehyde Using Partially Purified Pyruvate Decarboxylase (PDC),Biotechnology and Bioengineering, 49(1):52-62 (1996).

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