Process for production of piperidine derivatives

Details Process for production of piperidine derivatives Process for production of piperidine derivatives

2005-07-19

2005-07-19

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S209000, C546S210000, C546S216000, C546S240000, C544S034000, C544S096000, C544S299000, C540S469000, C540S470000, C540S488000, C540S492000

Reexamination Certificate

active

06919458

ABSTRACT:
The present invention relates to a process for preparing piperidine derivative compounds of the formulae:whereinn is 0 or 1;R1is hydrogen or hydroxy;R2is hydrogen;or, when n is 0, R1and R2taken together form a second bond between the carbon atoms bearing R1and R2, provided that when n is 1, R1and R2are each hydrogen;R3is —COOH or —COOR4;R4is an alkyl or aryl moiety;A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, alkoxy, and other substituents,The process comprises providing a regiosomer of the following formula:whereinZ is —CG1G2G3,m is an integer from 1 to 6;Q and Y are the same or different and are selected from the group consisting of O, S, and NR5;G1, G2, and G3are the same or different and are selected from the group consisting of OR8, SR8, and NR8R9;R6and R7are the same or different and are selected from the group consisting of hydrogen, an alkyl moiety, an aryl moiety, OR8, SR8, and NR8R9; andR5, R8, and R9are the same or different and are selected from the group consisting of hydrogen, an alkyl moiety, and an aryl moietyand converting the regioisomer to the piperidine derivative compound with a piperidine compound.

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