Process for production of phosphine-borane complexes

Details Process for production of phosphine-borane complexes Process for production of phosphine-borane complexes

2004-05-18

2009-06-02

Sullivan, Daniel M (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Boron containing

Reexamination Certificate

active

07541498

ABSTRACT:
A process for the production of phosphine-borane complexes represented by the general formula:or salts thereof: [wherein R1, R2and R3are each independently a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heterocyclic group (with the proviso that R1and R2together with the adjacent phosphorus atom may form a 4- to 6-membered ring)], characterized by converting a compound represented by the general formula:in a solvent in the presence of a borane reagent: [wherein each symbol is as defined above].

REFERENCES:
patent: 2003/0166978 (2003-09-01), Tsutsumi et al.
patent: 2005/0027124 (2005-02-01), Goto et al.
patent: 2003206295 (2003-07-01), None
Keglevich, G. et al. “Synthesis of phosphine-borane complexes of P-heterocycles”, J. Organometallic Chemistry, (1996), 516, 139-145.
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Keglevich, G. et al., “Convenient method for the reduction of the double-bond of cyclic vinylphosphine oxides using borane” (2000) Synthetic Communications 30(23), 4221-4231.
U. Schmidt, et al., “A Useful Synthesis of (R,R)-1,2-Ethanediylbis[(o-methoxyphenylphosphine] the Ligand of the Enantioselective Catalyst [Rh(COD) (DIPAMP)]+BF4”, Synthesis, (1991), pp. 655-657.
G. Keglevich, et al., “Synthesis of Phosphine-Boraine Complexes of P-heterocycles”, Journal of Organometallic Chemistry, (1996), vol. 516, pp. 139-145.
K. Shioji, et al., “Novel Synthesis of P-chiral Hydroxymethylphosphine-Boranes Through Lipase-Catalyzed Optical Resolution”, Bull. Chem. Sox. Jpn., (2003), vol. 76, pp. 833-834.
European Search Report issued Dec. 4, 2008 in EP 04733647.4.
Stankevic, M. et al., “An Expedient Reduction ofsec-Phosphine Oxides tosec-Phospine-boranes by BH3·SMe2”,Synlett, (2003), No. 7: 1012-1016.

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