Process for production of optically active oxazolidinone derivat

Details Process for production of optically active oxazolidinone derivat Process for production of optically active oxazolidinone derivat

1983-08-12

1986-05-13

Marantz, Sidney

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435121, C07B 1902

Patent

active

045886946

ABSTRACT:
A process for preparing the optically active oxazolidinone derivative [(S)-I] by utilizing microorganisms or enzymes having a stereoselective esterase activity capable of asymmetrically hydrolyzing the racemates of the acyloxyoxazolidinone derivative [(R,S)-II], by separating the unreacted compound [(S)-II] from the hydrolyzed compound [(R)-I] and by hydrolyzing the compound [(S)-II]. The compounds are useful as intermediates for preparing optically active .beta.-adrenergic blocking agents.

REFERENCES:
patent: 3607651 (1971-09-01), Moroe
patent: 3919239 (1975-11-01), Nakagawa
patent: 4332905 (1982-06-01), Olivieri
patent: 4461835 (1984-07-01), Sih
patent: 4481362 (1984-11-01), Nakai
patent: 4489208 (1984-12-01), Olivieri
Tsuda, Yoshisuke et al., Chem. Pharm. Bull., vol. 29, No. 19, pp. 3593-3600, 1981.

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