Process for production of O-alkylated rapamycin derivatives

Details Process for production of O-alkylated rapamycin derivatives Process for production of O-alkylated rapamycin derivatives

2007-03-20

2007-03-20

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

11067718

ABSTRACT:
Disclosed herein is a process for production of an O-alkylrapamycin derivative represented by the general formula (1) below by reaction between rapamycin and alkyl triflate in an organic solvent, characterized in that the reaction is carried out in the presence of trialkylamine.(where R denotes alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl.)This process is capable of producing O-alkylrapamycin derivative efficiently owing to improvement in reaction yields for O-alkylation.

REFERENCES:
patent: 2005/0101624 (2005-05-01), Betts et al.
patent: 2005/0131008 (2005-06-01), Betts et al.
patent: 94/09010 (1994-04-01), None
L.A. Sorbera et al., “Drug of the Future”, SDZ-RAD, Jan. 24, 1999, pp. 22-29, Prous Science, P.O. Box 540, 08080 Barcelona, Spain.
European Search Report.
Moenius, TH et al.: “Tritium Labelling of RAD001-A New Rapamycin Derivative”, Journal of Labelled Compounds and Radiopharmaceuticals, 43, pp. 113-120, 2000.
Moenius, TH et al.: “C-14 Labelling of NVP RAD001-A New Rapamycin Derivative”, Journal of Labelled Compounds and Radiopharmaceuticals, 42, pp. 29-41, 1999.

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