Refrigeration – Processes – Treating an article
Reexamination Certificate
2005-03-08
2005-03-08
Doerrler, William C. (Department: 3744)
Refrigeration
Processes
Treating an article
C062S070000, C264S013000
Reexamination Certificate
active
06862890
ABSTRACT:
The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.
REFERENCES:
patent: 1393383 (1921-10-01), Linebarger
patent: 2751762 (1956-06-01), Colton
patent: 3484946 (1969-12-01), Sauer
patent: 3653222 (1972-04-01), Dunn et al.
patent: 3672182 (1972-06-01), Stowasser et al.
patent: 3721725 (1973-03-01), Briggs et al.
patent: 3928566 (1975-12-01), Briggs et al.
patent: 4077227 (1978-03-01), Larson
patent: 4323478 (1982-04-01), Adams et al.
patent: 4470202 (1984-09-01), Buxton et al.
patent: 4704873 (1987-11-01), Imaike et al.
patent: 4848094 (1989-07-01), Davis et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5208998 (1993-05-01), Oyler, Jr.
patent: 9013285 (1990-11-01), None
Heller, M. C. et al., “Protein Formulation and Lyophilization Cycle Design: Prevention of Damage Due to Freeze-Concentration Induced Phase Separation,”Biotechnology and Bioengineering, vol. 63, No. 2, Apr. 20, 1999, pp. 166-174.
Maa, Yuh-Fun et al., “Protein Inhalation Powders: Spray Drying vs Spray Freeze Drying,”Pharmaceutical Research, vol. 16, No. 2, 1999, pp. 249-254.
Rogers, T. L. et al., “Solution-Based Particle Formation of Pharmaceutical Powders by Supercritical or Compressed Fluid Co2and Cryogenic Spray-Freezing Technologies,”Drug Development and Industrial Pharmacy, vol. 27, No. 10, 2001, pp. 1003-1015.
S. Palakodaty and P. York, Phase Behavioral Effects on Particle Formation Processes Using Supercritical Fluids,Pharm. Res., vol. 16, 1999, pps. 976-985.
R. A. Bodmeier et al., “Polymeric Materials Formed by Precipitation with a Compressed Fluid Antisolvent, ”AlChE Journal, vol. 39, 1993, pps. 127-139.
R. A. Bodmeier et al., “Polymeric Microspheres Prepared by Spraying into Compressed Carbon Dioxide,”Pharm Res., vol. 12 1995, pps 1211-1217.
R. A. Rajewski et al., “Pharmaceutical Processing with Supercritical Carbon Dioxide,”Journal of Pharm. Sci., vol. 86, 1997, pps. 885-890.
K. P. Johnston et al., “Rapid Expansion From Supercritical to Aqueous Solution to Produce Submicron Suspensions of Water-Insoluble Drugs,”Biotechnol. Prog., vol. 16, 2000, pps. 402-407.
Barron Melisa K.
Hu Jiahui
Johnston Keith P.
Rogers True L.
Williams, III Robert O.
Board of Regents University of Texas System
Doerrler William C.
LandOfFree
Process for production of nanoparticles and microparticles... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for production of nanoparticles and microparticles..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for production of nanoparticles and microparticles... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3413644