Process for production of lower alkanoic acids

Details Process for production of lower alkanoic acids Process for production of lower alkanoic acids

1993-09-03

1994-09-06

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562607, 562608, C07B 5300, C07C 5308

Patent

active

053449754

ABSTRACT:
A process for production of lower alkanoic acids. A reaction mixture comprising a substituted malonic acid, an acid catalyst, and a limited amount of water is heated to a temperature sufficient to hydrolyze and decarboxylate the ester. The reaction mixture is maintained at the temperature by periodic addition of limited amounts of water, and the reaction is continued for a period of time sufficient to remove substantially all of the alcohol and carbon dioxide generated by the hydrolysis reaction, thereby converting substantially all of the ester to alkanoic acid. The process is particularly useful for the production of valproic acid.

REFERENCES:
patent: 2523490 (1950-09-01), Adams et al.
patent: 3579297 (1971-05-01), Ekblom
patent: 3661950 (1972-05-01), Larkin et al.
patent: 3786086 (1974-01-01), Skov et al.
patent: 4127604 (1978-11-01), Chignac et al.
patent: 4215225 (1980-07-01), Funk et al.
patent: 4317925 (1982-03-01), Weber et al.
patent: 5101070 (1992-03-01), Yamamoto et al.
B. S. Furniss et al., Vogel's Textbook of Practical Organic Chemistry, III, 133/134, pp. 494-495 (Longman, London & New York, 4th ed.) (1980).
Dario Landini et al., "Acid Hydrolysis of Carboxylic Esters in a Two-Phase System . . . ", J. Org. Chem. 1982, vol. 47, pp. 154-156 (1982).
B. Loev, "Acid Catalysed `Hydrolysis` of Esters," Chemistry and Industry, pp. 193-194 (Feb. 1, 1964).

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