Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1999-02-12
2000-11-21
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
435180, C12P 1320, C12N 1108
Patent
active
061501425
ABSTRACT:
A process for producing crystalline L-aspartic acid is disclosed essentially consisting of the steps of preparing a mix solution containing fumaric acid, ammonia and an alkaline metal hydroxide, reacting the mix solution with aspartase to give a reaction solution containing L-aspartate and crystallizing L-aspartic acid out of the reaction solution, wherein a further amount of ammonia is added to the reaction solution containing L-aspartate and subsequently fumaric acid is added thereto to crystallize L-aspartic acid. The process can provide crystalline L-aspartic acid of high purity in a good workability without the need of any complicated steps.
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patent: 5939296 (1999-08-01), Sakano et al.
Woods et al., Structural and Functional Relationships Between Fumarase and Aspartase, Biochem. J.--vol. 237, pp. 547-557 (1986).
Sakano Koichi, "Production of L-Aspartic Acid", Patent Abstracts of Japan, Pub. No. 07308195, Nov. 28, 1995.
Sakano Koichi, "Production of L-Aspartic Acid", Patent Abstracts of Japan, Pub. No. 07313178, Dec. 5, 1995.
Iwane Hiroshi, "Production of Aqueous Solution of L-Aspartic Acid Alkali or Alkaline Earth Metal Salt", Patent Abstracts of Japan, Pub. No. 10337195, Dec. 22, 1998.
Komatsuzaki Satomi
Mukouyama Masaharu
Lilling Herbert J.
Nippon Shokubai Co. , Ltd.
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