Process for production of ioversol

Details Process for production of ioversol Process for production of ioversol

1990-01-31

1991-03-05

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

424 5, 564156, C07C23300, C07C23500, C07C23700, C07C23900

Patent

active

049979833

ABSTRACT:
A process for the production of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiod oisopht alamide wherein a mixture of 1,1,2-trichloroethane and 5-[(N-(2-acetoxyethyl)acetoxyacetamido]N,N'-bis(2,3-diacetoxypropyl)-2,4,6 -triiodoisophthalamide (hexaacetate) is distilled to remove 1,1,2-trichloroethane, at least a part of which is distilled as an azeotrope with water, so that a solvent exchange is effected to produce a mixture of hexaacetate in water. Hydrolysis of hexaacetate produces the desired product.

REFERENCES:
patent: 3701771 (1972-10-01), Almen et al.
patent: 4001323 (1977-01-01), Felder et al.
patent: 4021481 (1977-05-01), Almen et al.
patent: 4250113 (1981-02-01), Nordal et al.
patent: 4364921 (1982-12-01), Speck et al.
patent: 4396598 (1983-08-01), Lin

Affiliated with

Also associated with

Rating

Process for production of ioversol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for production of ioversol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for production of ioversol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-498290