Process for production of hydroxocobalamin

Details Process for production of hydroxocobalamin Process for production of hydroxocobalamin

1992-09-14

1994-08-16

Brown, Johnnie R.

Chemistry: electrical and wave energy

Processes and products

Processes of treating materials by wave energy

536 2641, 536 2642, 536 2643, 20415764, 20415767, C07H 2300, C07D40314

Patent

active

053384180

ABSTRACT:
A process for the production of hydroxocobalamin that eliminates cyanocobalamin as an intermediate. Co-enzyme-type vitamin B.sub.12 is first absorbed to a divinylbenzene/styrene resin which is washed with warm water and then eluted with a solution containing at least 25% of a lower alcohol. The eluate is then irradiated with a light that causes the conversion of coenzyme-type vitamin B.sub.12 to hydroxocobalamin. Finally, the solution of hydroxocobalamin is treated with alumina or silica which binds the impurities leaving behind the highly purified hydroxocobalamin in the flow-through.

REFERENCES:
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patent: 2668137 (1954-02-01), Briggs et al.
patent: 2694679 (1954-11-01), Holland et al.
patent: 2695862 (1954-11-01), Rickes et al.
patent: 2830009 (1958-04-01), Ziegler
patent: 3448099 (1969-06-01), Boige
patent: 4383110 (1983-05-01), Kinoshita et al.
Tetsuo Toraya, "Vitamin B12 and Related Compounds", Vitamin Science II:493-494, 1980 (partial translation enclosed).

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