Process for production of gabapentin intermediate

Details Process for production of gabapentin intermediate Process for production of gabapentin intermediate

2005-04-19

2005-04-19

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C568S376000

Reexamination Certificate

active

06881843

ABSTRACT:
The invention relates to a novel process for producing a the intermediary compound α,α′,dicyano-β,β-pentamethyleneglutarimide. The process includes the steps of reacting a ketone such as cyclohexanone with ethylcyanoacetate in the presence of ammonium hydroxide.

REFERENCES:
patent: 4024175 (1977-05-01), Satzinger et al.
patent: 5091567 (1992-02-01), Geibel et al.
patent: WO9733858 (1997-09-01), None
Holder, R. W. et al., “Geminate-Substituted Cyclopentadienes. 1. Synthesis of 5,5-Dialkylcyclopentadienes via 4,4-Dialkylcyclopent-2-en-l-ones”,J. Org. Chem.1982, vol. 47, pp. 1445-1451.
Thorpe et al.; paper entitled, The Formation and Reactions of Imino Compounds: Part XVIII. The Condensation of cycloHexanones with Cyanoacetamide Involving the Displacement of an Alkyl Group. J. Chem. Soc. 1913, pp. 1586-1600.
Vogel, A.I., paper entitled Physical Properties and Chemical Constitution: Part II. Esters of ββ-Substituted Glutaric Acids. J. Chem. Soc., 1934, pp. 1758-1765.

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