Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1980-10-02
1981-12-01
Rosen, Sam
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
260112R, 424 99, A61K 3700, A61K 3522, C07G 700
Patent
active
043036503
ABSTRACT:
The invention provides a novel process for the production of erythropoietin, which is a promising medicine for curing anemia, from human urine containing the same. The inventive method comprises adjusting the pH value of the urine in the range from 6 to 8, if the pH value of the urine is out of this range, and contacting the thus pH-controlled urine with a specific adsorbent so as that the erythropoietin is selectively adsorbed on the adsorbent. The adsorbed erythropoietin is then eluted out by use of an eluant solution to give the product in a partially purified form.
REFERENCES:
patent: 3865801 (1975-02-01), Chiba et al.
Miyake et al.-The J. of Biol. Chem., vol. 252, Aug. 1977, pp. 5558-5564.
Espada et al.-Chem. Abst. vol. 73 (1970) p. 94956y.
Hiratani Hajime
Takezawa Kenji
Ajinomoto Co. Inc.
Japan Chemical Research Co., Ltd.
Rosen Sam
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