Process for production of cephalosporin C

Details Process for production of cephalosporin C Process for production of cephalosporin C

2003-09-16

2009-06-30

Prouty, Rebecca (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

C536S023200, C435S320100, C435S252300, C435S325000, C435S254110, C435S196000

Reexamination Certificate

active

07553635

ABSTRACT:
The present invention relates to isolated nucleic acid molecules which code for a new protein fromAcremonium chrysogenum, to vectors which comprise such a nucleic acid molecule, toAcremonium chrysogenumhost cells which have been transformed with such a vector and to a method for production of cephalosporin C using such transformed host cells.

REFERENCES:
Connerton et al., “An Acetate-Sensitive Mutant of Neurospora-Crassa Deficient in Acetyl-Coa Hydrolase”, Journal of General Microbiology, vol. 138, No. 9, pp. 1797-1800 (1992).
Malmberg et al., “Identification of Rate-Limiting Steps in Cephalosporin C Biosynthesis in Cephalosporium Acremonium: A Theoretical Analysis”, Applied Microbiology and Biotechnology, vol. 38, No. 1, pp. 122-128 (1992).
Marathe et al., “Duplication-Induced Mutation of a New Neurospora Gene Required for Acetate Utilization Properties of the Mutant and Predicted AMino Acid Sequence of the Protein Product”, Molecular and Cellular Biology, vol. 10, No. 6, pp. 2638-2644 (1990).
Shen et al., “Levels of Isopenicillin N Synthetase and Deacetoxycephalosporin C Synthetase in Cephalosporium-Acremonium Producing High and Low Levels of Cephalosporin C”, Bio-Technology, vol. 4, No. 1, pp. 61-62 (1986).
Skatrud et al, “Use of Recombinant DNA to Improve Production of Cephalosporin C by Cephalosporium-Acremonium”, Bio-Technology, vol. 7, No. 5, pp. 477-485 (1989).
Ullan et al., “A Novel Epimerization System in Fugal Secondary Metabolism Involved in the Conversation of Isopenicillin N into Penicillin N in Acremonium Chrysogenum”, Journal of Biological Chemistry, vol. 277, No. 48, pp. 46216-46225 (2002).
Knihinicki et al., Chiral Inversion of 2-Arylpropionic Acid Non-Steroidal Anti-inflammatory Drugs-II, Racemization and Hydrolysis of (R)- and (S)-Ibuprofen-CoA Thioesters, Biochem. Pharmacol., 1991, vol. 42, No. 10, pp. 1905-1911.
Shieh et al., Purification and Characterization of Novel “2-Arylpropionyl-CoA Epimerases” from Rat Liver Cytosol and Mitochondria, J. Biol. Chem., 1993, vol. 268; No. 5, pp. 3487-3493.

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