Process for production of carebastine

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S221000

Reexamination Certificate

active

08067604

ABSTRACT:
Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:

REFERENCES:
patent: 4254129 (1981-03-01), Carr et al.
patent: 4254130 (1981-03-01), Carr et al.
patent: 4550116 (1985-10-01), Soto et al.
patent: 5589487 (1996-12-01), D'Ambra
patent: 5994549 (1999-11-01), D'Ambra
patent: 6057456 (2000-05-01), Hartwig et al.
patent: 6153754 (2000-11-01), D'Ambra et al.
patent: 6201124 (2001-03-01), D'Ambra et al.
patent: 6242606 (2001-06-01), Krauss et al.
patent: 6444824 (2002-09-01), D'Ambra et al.
patent: 6448406 (2002-09-01), D'Ambra et al.
patent: 6452011 (2002-09-01), D'Ambra et al.
patent: 6458958 (2002-10-01), D'Ambra et al.
patent: 6743941 (2004-06-01), Schroeder et al.
patent: 6919458 (2005-07-01), D'Ambra et al.
patent: 6974872 (2005-12-01), D'Ambra et al.
patent: 2003/0166682 (2003-09-01), Milla
patent: WO9403170 (1994-02-01), None
patent: WO9709983 (1997-03-01), None
patent: WO2005077884 (2005-08-01), None
Scientific Background on the Nobel Prize in Chemistry 2010 “Palladium-Catalyzed Cross Couplings in Organic Synthesis” Oct. 6, 2010, pp. 1-12.
Stephen H. Kawai, Robert J. Hambaleck and George Just, “A Facile Synthesis of an Oxidation Product of Terfenadine”, J. Org. Chem., 59, 2620-2622 (1994).
Morten Jorgensen, Sunwoo Lee, Xiaoxiang Liu, Joanna P. Wolkowski, and John F. Hartwig, “Efficient Synthesis of a-Aryl Esters by Room-Temperature Palladium-Catalyzed Coupling of Aryl Halides with Ester Enolates”, J. Am. Chem. Soc. 124, 12557-12565 (2002).
Xiaoxiang Liu and John F. Hartwig, “Palladium-Catalyzed Arylation of Trimethylsilyl Enolates of Esters and Imides. High Functional Group Tollerance and Steroselective Synthesis of a-Aryl Carboxylic Acid Derivatives”, J. Am. Chem. Soc. (2004) 126, 5182-5191.
Darcy Ann Culkin “Synthesis and Reactivity of Palladium Complexes of Functionalized Alkyls. Selection of Catalysts for the alpha-Arylation of Nitriles and Amides” Yale University May 2004, pp. 2, 12-40.
Koch et al. “(+1-1-(3S,4R)-13-(4-Phenylbenzy1)-4-hydroxychroman-7-yllcyclopentane Carboxylic Acid, A Highly Potent, Selective Leukotriene B4 Antagonist with Oral Activity in the Murine Collagen-Induced Arthritis Model” Journal of Medicinal Chemistry, 1994, 37, 3197-3199.
Sakamoto et al. “Synthesis of methyl 2-(Heteoraryl)propanolates via palladium catalyzed reaction” Heterocycles 1993, 36, 25-9-2512.
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface and Chapter 8, pp. 279-308.
Agnelli et al. “Synthesis of Arylacetates by the Palladium-catalyzed Cross-Coupling of Aryl Bromides and Copper (ii) Enolates” Tetrahedron Letters 1998, 39, 8807-8810.
Hama, et al. “Palladium-Catalyzed Arylation of Esters and Amides under More neutral Conditions” Journal of the American Chemical Society 2003, 125, 11176-11177.
Carfagna, Carla; Musco, Alfred; Sallese Gianna; Sanit, Roberto; Fiorani, Tiziana “Palladium-Catalyzed Coupling Reactions of Aryl Triflates or Halides with Ketene Trimethylsilyl Acetals. A New route to Alkyl 2-Arylalkanoates” Journal of Organic Chemistry, 1991, 56, 261-263.
Millard, A.A.; Rathke, Michael W. “A Nickel Catalyst for the Arylation and Vinylation of Lithium Ester Enolates” Journal of the American Chemical Society 1977, 99, 4833-4835.
Ei-ichi Negishi Handbook of Organopalladium Chemistry for Organic Synthesis, John Wiley & Sons, 2002, 215-227.
Nagano, T.; Hayashi, T. “Iron-catalyzed Grignard Cross-coupling with Alkyl Halides Possessing b-Hydrogens” Organic Letters 2004, 6 (8), 1297-1299.
Spessard, G.O. and Miessler, G.L., Organometallic Chemistry, 1997, Prentice Hall, pp. 161-178.
Zenk, R. and Partzsch, S. “Organic boronic acids and boronic acid esters in industrial synthesis” Chimica Oggi May 2003 70-73.
T. Fujii, S. Matsumoto, H. Amejima, T. Hatoyama, M. Nakao, A. Kagemoto, K. Tanaka and H. Miyazaki, “Absorption, Distribution, Metabolism and Excretion of [14C]Ebastine after a Single Administration in Rats”, Arzneim.-Forsch./DrugRes. 44(I), Nr. 4 (1994).
Furstner, A.; Leitner, A.; Mendez, M.; Krause, H. “Iron-Catalyzed Cross-Coupling Reactions” Journal of the American Chemical Society 2002, 124, 13856-13863.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for production of carebastine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for production of carebastine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for production of carebastine will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4264761

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.