Process for production of anthracycline compound R20X2

Details Process for production of anthracycline compound R20X2 Process for production of anthracycline compound R20X2

1987-06-30

1989-08-08

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

2603514, 2603515, C07H 1524

Patent

active

048554146

ABSTRACT:
An anthracycline compound, R20X2, of the following formula (II) is produced by a process which comprises subjecting an anthracycline compound, R20X3, of the following formula (I) or a salt thereof to reaction in the co-presence of (1) acetone and/or dimethylformamide and (2) an aqueous solution containing ammonium ion and/or trialkylamine. ##STR1## The anthracycline compound, R20X2, can be produced not only by the cultivation of actinomycetes but also, in accordance with the process as shown above, by chemical conversion of the anthracycline compound, R20X3, in a high yield.

REFERENCES:
patent: 3862225 (1975-01-01), Conover et al.
patent: 4263428 (1981-04-01), Apple et al.
patent: 4612371 (1986-09-01), Yoshimoto et al.
Mar., Advanced Organic Chemistry, 1977 2 ed., pp. 356-357.

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