Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1977-03-03
1979-09-11
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
542455, 546153, 546157, 546159, 546 83, C07D21540
Patent
active
041676386
ABSTRACT:
An improved process for producing 8-NHR quinolines from 8-aminoquinolines disclosed. The process comprises reacting 8-aminoquinolines with a substituted alkyl halide in the presence of an amine having a boiling point of 80.degree.-90.degree. C. The amine functions as an acid acceptor whereby the amine salt formed may be efficiently separated from the 8-NHR quinoline formed without expensive or time consuming purification steps. The reaction may be carried out in the presence of a solvent such as an alcohol.
REFERENCES:
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Shetty et al., J. Med. Chem. 20, 1349-1351, (1977).
Shetty et al., J. Med. Chem. 21, 995-998, (1978).
Montagne et al., J. Med. Chem. 20, 1122-1127, (1977).
Chen et al., J. Med. Chem. 20, 1107-1109, (1977).
Chen Eugene H.
Nodiff Edward A.
Saggiomo Andrew J.
Bellamy Werten F. W.
Daus Donald G.
Gapcynski William G.
Rivers Diana G.
The United States of America as represented by the Secretary of
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