Process for production of 5-fluorouracil and its derivatives

Details Process for production of 5-fluorouracil and its derivatives Process for production of 5-fluorouracil and its derivatives

1977-06-09

1978-10-24

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

544313, C07D23954, C07H 1906

Patent

active

041222512

ABSTRACT:
A process for production of 5-fluorouracil and its derivatives which comprises reacting a cytosine compound of the formula: ##STR1## wherein R is a hydrogen atom or a saccharide residue with fluorine or fluorine fluorosulfonate (FOSO.sub.2 F) in an aqueous medium to give the corresponding 5-fluorouracil compound of the formula: ##STR2## wherein R is as defined above.

REFERENCES:
patent: 2802005 (1957-08-01), Heidelberger
patent: 3635977 (1972-01-01), Lutz
patent: 3682917 (1972-08-01), Knuniants et al.
patent: 3954758 (1976-05-01), Schuman et al.
patent: 4029661 (1977-06-01), Schuman et al.

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