Process for production of 3-hydroxy-3-methylphthalide or the nuc

Details Process for production of 3-hydroxy-3-methylphthalide or the nuc Process for production of 3-hydroxy-3-methylphthalide or the nuc

1980-06-02

1981-11-03

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

562459, C07D30788

Patent

active

042985307

ABSTRACT:
A process for producing 3-hydroxy-3-methylphthalide or its nuclearly substituted derivative of the following general formula ##STR1## wherein R represents a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or a carboxyl group, and n is 0 or an integer of 1 to 3,
which comprises reacting phthalic anhydride or its nuclearly substituted derivative of the following general formula ##STR2## wherein R and n are as defined, with malonic acid at an elevated temperature in at least one solvent selected from the group consisting of dialkylformamides, dialkylsulfoxides and aliphatic lower carboxylic acids in the presence of, as a catalyst, a salt of an inorganic or organic acid with a metal selected from the group consisting of metals of Groups IA, IIA, IIIB and VIII of the periodic table, manganese, copper and zinc.

REFERENCES:
Finkelstein et al., J. Org. Chem., vol. 32, p. 3229.
Yale, J. Ameri. Chem. Soc. vol. 69, p. 1547.

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