Process for production of 2-phosphated esters of ascorbic acid

Details Process for production of 2-phosphated esters of ascorbic acid Process for production of 2-phosphated esters of ascorbic acid

1990-10-17

1992-06-02

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07F 909

Patent

active

051188171

ABSTRACT:
A process for the production of 2-phosphated esters of ascorbic acid by subjecting an ascorbic acid optionally protected at the 5- and 6-positions to phosphorylation with maintaining the concentration of the optionally protected ascorbic acid in a reaction mixture at less than 0.3 M and, if necessary, removing any protecting group is disclosed. 2-Phosphated ester of ascorbic acid can be produced with a good yield in an industrial scale by this process.

REFERENCES:
patent: 3671549 (1972-06-01), Hinkley
patent: 3718482 (1973-02-01), Hinkley
patent: 3749680 (1973-07-01), Hinkley
patent: 4179445 (1979-12-01), Sieb et al.
patent: 4647672 (1987-03-01), Seib et al.
patent: 4939128 (1990-07-01), Kato et al.
Chem. Pharm. Bull. 17, No. 2, 1969, pp. 381-386, Nomura et al., "Studies on L-Ascorbic Derivatives. II. L-Ascorbic Acid 3-Phosphate and 3-Pyrophosphate."
Carbohydrate Research, 67, pp. 127-138, 1973, Lee et al., "Chemical Synthesis of Several Phosphoric Esters of L-Ascorbic Acid."

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